Take a second, too, to get the latest info about the conditions around Colorado. There are several great tools to do this. For the latest in road and traffic info, be sure to check out the Colorado Department of Transportation's COTRIP site. There, you will find maps, traffic cameras and info regarding the latest road conditions.
Too, CDOT maintains a twitter feed @ColoradoDOT. Obviously (and not just because of the new law prohibiting you from doing so...) don't check the twitter feed while driving, but if you stop or you have someone who can check it for you, do so. They are posting great, timely info about plow activities, closures and road conditions.
Also, be sure to keep an eye on the weather. This is Colorado. The weather changes fast, particularly in the high country. So, make sure you check in with the National Weather Service - Colorado Weather site during your travels, too.
And, as always... pack an emergency kit for your car. You never know what might happen. You might need it. If you don't need it, great. If you need it and you didn't pack it, you will regret it. Don't be a statistic.